About the ProductRefresh P.M. is a preservative free lubricant eye ointment supplied in a sterile...
Dry eye product guide
Best Nighttime Eye Drops, Gels, and Ointments
If your eyes are driest first thing in the morning, the answer is usually a thicker drop at night. Gels and ointments stay on the surface for hours, protecting the eye while you sleep. For many people, a preservative-free ointment or gel at bedtime is a good place to start. If morning dryness is severe, persistent, or comes with vision changes, see an eye doctor.

Key takeaways
- Morning dryness usually means the eye dried out overnight, so a thicker drop at bedtime can help.
- Gels are thicker than artificial tears and last longer, with brief blurring. Ointments are the thickest and give the longest overnight protection.
- Preservative-free nighttime options are a good choice for sensitive eyes used nightly.
- Use gels and ointments right before sleep, since they blur vision for a few minutes.
- If mornings are always rough, ask an eye doctor about incomplete lid closure at night.
Quick answer
What should I use at night?
For many people with morning dryness, a good place to start is a gel or ointment right before bed, which stays on the surface through the night. If morning dryness is severe, persistent, or comes with vision changes, see an eye doctor.
Recommended nighttime drops, gels, and ointments
These overnight options range from a gel to thicker ointments. Use them as the last thing before sleep. Descriptions are the manufacturer's own.
About the ProductOptase Hylo Night is a preservative free eye ointment supplied in a 5...
About the ProductA carton of 30 sterile single-use vials of lubricant eye gel, 0.014 oz...
About the ProductSystane Nighttime is an ophthalmic ointment supplied in a 3.5 g tube (1/8...
Where to start
Match the product to how your mornings feel, then confirm the choice with your eye doctor if symptoms persist.
- Best first stepA preservative-free overnight ointment, such as Refresh PM
- Lighter overnight reliefA thicker gel, such as iVIZIA Lubricant Eye Gel
- Eyes that do not fully close at nightAdd a moisture sleep mask, such as EyeEco EyeSeals 4.0
- Nightly use with sensitive eyesOptase Hylo Night or Ocusoft Retaine PM
Nighttime products customers order most
Listed in order of how often Dry Eye Rescue customers buy them. Descriptions are the manufacturer's own.
About the ProductOptase Hylo Night is a preservative free eye ointment supplied in a 5...
About the ProductAvailable options: Black, Clear.People shop for a sleep shield as part of a...
About the ProductA carton of 30 sterile single-use vials of lubricant eye gel, 0.014 oz...
About the ProductRefresh P.M. is a preservative free lubricant eye ointment supplied in a sterile...
About the ProductRetaine PM is an over the counter lubricant eye ointment supplied in one...
About the ProductSystane Nighttime is an ophthalmic ointment supplied in a 3.5 g tube (1/8...
Gel or ointment, which should I choose?
Still deciding? Here is a simple way to pick.
Choose a gel if
You want overnight relief with less blurring than an ointment.
Choose an ointment if
You want the longest overnight protection and use it right before sleep.
Choose a preservative-free option if
Your eyes are sensitive and you use a nighttime product every night.
See a doctor if
Morning dryness is severe, persistent, or you suspect your lids do not fully close at night.
Worth understanding
Why are my eyes driest in the morning?
During sleep, tear production slows and the lids may not fully close, so the surface of the eye can dry out overnight. That is why dry eye is often worst when you wake. A regular watery drop does not last long enough to help through the night, so the nighttime tools are gels and ointments, which are thicker and stay on the eye for hours.
What to avoid. A thin, watery daytime drop usually does not last through the night, so it may not be the best tool for morning dryness on its own. And because ointments blur vision for a few minutes, put them in as the last thing before sleep, not before reading or screens. If mornings stay dry despite a nighttime product, that is a sign to see an eye doctor rather than simply adding more.
Source: TFOS DEWS III Management and Therapy Report, American Journal of Ophthalmology (2025). Full citation at the end of this page.
How to choose and use a nighttime product
Gels are a middle ground, thicker than artificial tears and longer lasting, with only brief blurring. Ointments are the thickest and give the longest protection, but they blur vision more, so they are a bedtime-only tool. Both come in preservative-free options for sensitive eyes. Apply a small amount inside the lower lid as the last thing before sleep.
Daytime eye drops
Gels
Ointments
Moisture sleep mask
Build a nighttime dry eye relief routine
A few simple habits at bedtime can make mornings far more comfortable.
-
Use a thicker gel or ointment right before sleep
A gel or ointment stays on the surface much longer than a watery drop, which protects the eye through the night. Put it in as the last thing before sleep, since it blurs vision briefly.
-
Add a moisture sleep mask if your eyes do not fully close at night
A hydrating sleep mask holds moisture around the eyes and shields them from drying air overnight.
-
Set up your bedroom for comfort
Point fans and vents away from your face, and add a humidifier if the room is dry.
-
See a dry eye doctor if mornings are always rough
Persistent morning dryness can point to lids that do not fully close at night, which an eye exam can check.
Still not sure what you need?
If morning dryness is severe, persistent, or affecting your vision, it may be time to see an eye doctor, who can check whether your lids fully close at night. Dry Eye Rescue works with a network of over 5,000 eye care professionals and can help you find one near you.

Most common questions
Why are my eyes driest in the morning?
During sleep, tear production slows and the lids may not fully close, so the surface dries out overnight and feels worst when you wake.
What is the best eye drop to use at night?
A gel or ointment, which stays on the surface far longer than a watery drop. Use it right before sleep, since it blurs vision briefly.
What is the difference between a nighttime gel and an ointment?
A gel is thinner, lasts a while, and blurs less. An ointment is thickest, lasts longest, and blurs more, so it is a bedtime-only tool.
Do nighttime ointments blur your vision?
Yes, for a few minutes after you put them in. That is why they are used right before sleep.
Are there preservative-free nighttime options?
Yes. Several nighttime ointments are preservative-free, which is a good choice for sensitive eyes used every night.
How do I apply a nighttime ointment?
Pull down the lower lid and place a small ribbon inside it, then blink to spread it. Do it as the last thing before sleep.
When should I see an eye doctor about morning dryness?
If mornings are always rough, an eye doctor can check for incomplete lid closure at night and other causes.
Where can I find a dry eye doctor near me?
Use the Dry Eye Rescue Doctor Locator to find an eye care professional near you from our network of over 5,000 providers.
Sources
- Tear Film and Ocular Surface Society. TFOS DEWS III Management and Therapy Report. American Journal of Ophthalmology. 2025. ajo.com/article/S0002-9394(25)00274-0
Educational information only. This page does not replace advice from your eye care professional. Individual needs vary, and persistent or worsening symptoms should be evaluated by a professional. Ask your eye doctor if symptoms persist, and follow the product label. Product and brand names referenced are trademarks of their respective owners. These statements have not been evaluated by the Food and Drug Administration.



